For example, AICAR, a direct activator of AMPK, has been reported to stabilize caspase-8 precursors, enhance RIPK3 degradation, and suppress necroptosis in pancreatic acinar cells, thereby attenuating disease severity and converting SAP in obese mice to a milder form.259 However, Boonchan et al.260 developed AP models using RIPK3−/− or MLKL−/− mice and reported that RIPK3- and MLKL-mediated necroptosis plays a protective role in AP, cautioning against the indiscriminate use of necroptosis inhibitors for treatment. Here, CASP8 is linked to alkaline phosphatase measurement.