In contrast, M2 macrophages are associated with tissue repair and fibrosis through the secretion of anti-inflammatory mediators, including IL-10, arginase-1, CCL24, and CCL22.323 In the early stages of AP, necrotic acinar cells create a unique metabolic microenvironment that promotes M1 polarization of macrophages.324 This process is mediated by the release of various factors, including DAMPs325 and chemokines such as CXCL10.326 These signals influence resident macrophages located near acinar cells,297 thereby exacerbating the progression of pancreatitis. The gene discussed is IL10; the disease is alkaline phosphatase measurement.