In this pathway, RIPK3 phosphorylates MLKL, leading to its oligomerization and translocation to the plasma membrane to execute necroptosis.251 Necroptosis is considered a more aggressive form of cell death and may represent a predominant mode of acinar cell death in AP.258 Studies have shown that genetic deletion of RIPK3 or pharmacological inhibition of the RIPK1/RIPK3 pathway via necrostatin can significantly reduce AP severity. This evidence concerns the gene RIPK1 and alkaline phosphatase measurement.