NFKB1 and pancreatitis: Kaempferol, for example, exerts anti-inflammatory effects by modulating the LPS–TLR4–NF-κB and IRE1–JNK–CHOP pathways513,514 but is poorly soluble and stable.515 To address this, thioketone-modified liposomal nanocarriers (DTM@KA NPs) have been employed to significantly increase kaempferol bioavailability and alleviate pancreatic inflammation by promoting STAT6-mediated mitochondrial protein transport and Pink1/Parkin-regulated autophagy.516 Biomolecular carriers also present unique advantages in AP treatment.