In mouse embryonic fibroblasts deficient in LAMP-2, this fusion is impaired but can be restored by exogenous LAMP-2a administration.222,223 The degradation deficiency caused by LAMP impairment results in the accumulation of autophagosomes containing partially degraded cargo.224,225 In LAMP-2-deficient mice, lysosomal dysfunction leads to acinar cell vacuolation and spontaneous pancreatitis characterized by trypsinogen activation and acinar cell death.226 Therefore, targeting LAMP-1 and LAMP-2 to restore lysosomal integrity and function represents a promising therapeutic strategy for AP. The gene discussed is LAMP2; the disease is pancreatitis.