Pyroptosis can proceed via the classical pathway, which is caspase-1 dependent, or the nonclassical pathway, which is mediated by caspases -4, -5, and -11.251 In hyperlipidemia-induced AP models, M1-polarized macrophages activate the classical caspase-1-dependent pathway through the secretion of cathepsin S, which contributes to inflammation and pancreatic injury. This evidence concerns the gene CASP1 and hyperlipidemia.