Transcription factor EB (TFEB), a key regulator of lysosomal biogenesis and autophagy,229 has been increasingly implicated in experimental pancreatitis through its influence on lysosomal abundance and function, thereby modulating autophagic activity.219 For example, Wang et al. analyzed GFP-LC3 transgenic mice, acinar cell–specific TFEB knockout mice, TFEB/TFE3 double knockout mice, and human pancreatitis samples. Here, TFE3 is linked to pancreatitis.