TNF and acute respiratory distress syndrome: Similarly, Shengjiang decoction reduces the serum levels of amylase and TNF-α, upregulates IL-10, and improves multi-organ pathological injury in AP rats.480 In addition, Chaihuang Qingfu pills have been shown to lower the incidence of AP-ALI by inhibiting MMP9/NLRP3 pathway-mediated pyroptosis.481 Our group also reported that Zengye decoction can ameliorate SAP-related acute kidney injury by modulating the “microbiota–metabolite axis”.482