ORAI1 and alkaline phosphatase measurement: Inhibiting Orai1 activity reduces stromal interaction molecule-dependent extracellular Ca2+ influx induced by bile acids or alcohol, thereby preventing pancreatic duct secretion damage and potentially improving AP prognosis.206 For example, the calcium channel inhibitor CM4620 (Auxora, CalciMedica) selectively blocks the Orai1 channel and inhibits calcium influx, thereby significantly reducing acinar cell injury and inflammation in animal models.