Among these, the 10 most significant genes (GSTT2B, HMGA2, AC135050.2, ANKRD33B, MMP13, PLA2G2D, RASGEF1A, BIRC7, DCAF4L2, and CHMP7) may serve as potential genomic biomarkers for predicting which patients with NSCLC are most likely to respond to PD-1 immunotherapy. The gene discussed is DCAF4L2; the disease is non-small cell lung carcinoma.