Additionally, we identified 62 upregulated genes in nonresponder patients with NSCLC, with the top 10 most important being SPINK1, FEZF1, THBS4, BEST3, TESC, C6orf226, TSSK2, SFRP2, C1GALT1C1L, and RARRES1 (Figure 7). The gene discussed is THBS4; the disease is non-small cell lung carcinoma.