Notably, targeting STING via intracellular cGAMP and agonists suppressed T cell function and induced type I IFN and PDL1 expression, reinforcing the involvement of STING signaling cascade and subsequent type I IFN in the reprogramming of DCs to induce immune impairment in our co-culture system and in individuals with chronic HIV infection [61]. This evidence concerns the gene STING1 and HIV infectious disease.