We have demonstrated that during the interaction between mature DCs and T cells in the presence of HIV, the virus induces impaired responses with expression of, e.g., PDL1 and Galectin-9 on DCs, and programmed death-1 (PD-1) and CTLA4 on T cells [18–20], which is in line with findings in chronic HIV infection [14,21]. The gene discussed is CD274; the disease is HIV infectious disease.