Fig 4H illustrates differentially expressed gene GSTM3 and TFF1 between domains 3 and 14, where the spatial distribution of gene expression of these two genes indicates they are up-regulated in domain 14, and gene expression is significant between these two domains (p = 1.3E-26 for GSTM3, p = 7.9E-29 for TFF1). Evidence shows that GSTM3 is a multi-drug resistance gene [57], and TFF1 is associated with tumor differentiation [58]. Here, GSTM3 is linked to neoplasm.