BRCA1 and familial pancreatic carcinoma: Individuals with pathogenic BRCA variants face an elevated risk not only for breast and gynecologic cancers but also for pancreatic cancer (BRCA1: 1–3%, BRCA2: 3–5% by age 70), and male carriers for prostate cancer (BRCA1: 21%, BRCA2: 27% by age 75).