Apoe-null mice were rendered diabetic by STZ and were left untreated or were treated with DCO for 20 weeks (DCO-Extended), from week 1 to 11 (DCO-Early) or from week 9 to 19 (DCO-Late). Non-diabetic Apoe-null mice served as controls. This evidence concerns the gene APOE and Leri-Weill dyschondrosteosis.