BDNF and glioblastoma: Finally, carnosine has also been shown to stimulate the secretion of neurotrophins such as Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in human glioblastoma-derived U-87 MG cells, but not in neuronal SH-SY5Y cells, suggesting a cell type-specific mechanism of action [208].