This study aimed to explore the diagnostic and prognostic significance of integrating classical tumor markers, including alpha-fetoprotein (AFP), beta-human chorionic gonadotropin (β-HCG), and lactate dehydrogenase (LDH), with inflammatory hematological indices, including neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume-to-platelet ratio (MPV/PLT), in patients with testicular neoplasms. Here, AFP is linked to testicular neoplasm.