FMR1 and intervertebral disk degenerative disorder: Current guidelines from the American College of Medical Genetics and Genomics and the American Academy of Pediatrics recommend that FMR1 testing be included as part of the first-line diagnostic investigations for children with GDD or IDD, particularly when there is a family history suggestive of FXS [6] or other FMR1-related neurodevelopmental conditions [11].