↑ lifespan and organ protection: preserved diastolic function (Eisenberg et al. 2016), reduced liver fibrosis and hepatocellular carcinoma (Yue et al. 2017), improved metabolic parameters and gut barrier in diet‐induced obese mice (Ma et al. 2020), improved cognition linked to increased eIF5A hypusination and mitochondrial function (Schroeder et al. 2021), rejuvenated aged oocyte quality via enhanced mitophagy (Zhang et al. 2023). Here, EIF5A is linked to hepatocellular carcinoma.