This study investigates the prognostic value of two novel inflammatory biomarkers-the systemic inflammatory response index (SIRI) and C-reactive protein-to-albumin ratio (CAR)-in predicting disease progression and clinical outcomes in NF patients.<h4>Methods</h4>This retrospective cohort study analyzed clinical data from 192 patients with confirmed soft tissue infections, comprising 50 necrotizing fasciitis (NF) cases and 142 non-NF presentations. The gene discussed is CRP; the disease is fasciitis.