ANO1 and schizophrenia: Correlation analysis demonstrated a significant negative relationship between gene expression z-scores in ANO1 cKO and control mice (r = − 0.5788, R2 = 0.3350, p < 0.0001), suggesting that ANO1 deficiency induces transcriptomic alterations inversely related to typical expression profiles in schizophrenia (Fig. 4D).