CCL2 and Cachexia: For example, the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 (CCL2/CCR2) axis recruits neutrophils to the brain to induce anorexia and sarcopenia in patients with pancreatic cancer.75 Since inflammation plays a pivotal role in cachexia-associated anorexia, elevated intestinal permeability may represent a potential mechanism underlying central inflammation.