Indeed, 2-deoxy-D-glucose supplementation enhances hepatic ketogenesis and promotes ketone metabolism in skeletal muscle, which elevates ATP synthesis efficiency and blocks aberrant Cori cycling, thereby effectively preventing muscle atrophy.158 Tumor-secreted IL-6 inhibits peroxisome proliferator-activated receptor (PPAR) α, a transcriptional regulator of ketogenesis, diminishing hepatic ketogenic capacity in precachectic mice. Here, IL6 is linked to neoplasm.