The relatively high prevalence of cachexia in lung cancer patients is potentially due to anorexia, cytokines, and metabolic abnormalities.49 Interestingly, patients with epidermal growth factor receptor (EGFR)-mutated lung cancers have a lower risk of developing cachexia, possibly because these cancer cells tend to progress more slowly than those without EGFR mutations.30 However, comprehensive elucidation of the mechanisms driving cachexia in lung cancer patients may facilitate the development of targeted interventions and better outcomes for this vulnerable population. The gene discussed is EGFR; the disease is cancer.