Creatine supplementation effectively prevents tumor-induced increases in plasma homocysteine levels and hepatic oxidative stress, thereby alleviating tumor growth and weight loss.238 Compared with tumor-bearing rats, creatine intake diminishes plasma TNF-α and IL-6 levels and alleviates splenic morphological alterations, such as reduced white pulp and lymph follicle sizes, indicating that creatine may prevent skeletal muscle atrophy by modulating the tumor-induced proinflammatory milieu.239. Here, TNF is linked to neoplasm.