XDH and cancer: In cancer cachexia, energy metabolism is frequently disrupted by tumor proliferation and increased catabolism, resulting in reduced ATP and ADP levels in muscle tissue that normalize after tumor resection.269 Xanthine oxidase inhibitors hold promise as potential therapeutic agents to mitigate muscle wasting and cardiac dysfunction in cancer cachexia.270 In lung cancer patients, upregulated AMPK contributes to alleviating cancer-induced metabolic perturbations by preventing glucose intolerance and insulin resistance and decreasing glucose disposal in skeletal muscle and WAT.