Conversely, CD8+ memory T cells and CD95+CD8+ T cells inversely correlate with muscle function, suggesting that the infusion of specific T-cell subsets may restore a balanced T-cell profile, thereby mitigating muscle atrophy and alleviating cachexia in cancer-bearing mice.302 Nevertheless, the intricate nature of the immune system implies that multiple factors concurrently influence muscle function and mass, resulting in inconsistencies in research findings and thereby obscuring the precise role of T cells in cachexia (Fig. 6). Here, CD8A is linked to cancer.