These findings highlight the potential role of ATM-SNS crosstalk in cancer cachexia.156 However, another study reported that macrophages significantly promote beige adipose thermogenesis independently of the SNS after inducing sympathetic neuronal apoptosis with 6-hydroxydopamine in mice.284 M2 macrophage-derived TGF-β induces senescence in adipose progenitor cells and inhibits adipogenesis in aged mice. The gene discussed is TGFB1; the disease is cancer.