Recently, Bilgic et al. reported that OSM can increase the levels of EDA2R in muscle tissues, leading to increased skeletal muscle atrophy, suppressed adipocyte differentiation, and increased adipocyte degradation.382 Furthermore, depletion of OSMR in muscle fibers protects mice from weight loss and muscle wasting, which, at least in part, is attributed to suppression of the upregulation of Eda2r induced by tumors.382 In other words, in patients with cachexia, OSM has a significant effect on both muscle and fat metabolism. The gene discussed is EDA2R; the disease is Cachexia.