We previously reported that MRTFA promotes aortic dissection and aneurysm formation via MAPK14.19 MRTFA has been documented as a critical regulator that promotes vascular fibrosis, inflammation, and cell death, contributing to vascular disease.19,20,53 We thus asked whether MAPK14, in turn, activates MRTFA in a feedforward loop that amplifies VSMC degeneration. The gene discussed is MRTFA; the disease is dissection.