USP10 and triple-A syndrome: This finding, along with the observed reduction in MAPK14 activity in MRTFA-deficient VSMC cells, supports a novel positive feedback loop between MRTFA and MAPK14 in driving VSMC degeneration and AAA formation.19 Through a series of in vitro experiments, we demonstrated that MAPK14 stabilizes MRTFA by preventing ubiquitin proteasome degradation mediated by USP10, an understudied deubiquitinase in VSMCs.