PAX6 and aniridia: Congenital aniridia is a rare panocular disorder caused primarily by heterozygous mutations in the PAX6 gene In addition to the hallmark feature of iris hypoplasia, patients with aniridia frequently exhibit a broad spectrum of ocular abnormalities, including cataract, glaucoma, foveal hypoplasia, and notably, a progressive corneal opacification known as aniridia-associated keratopathy (AAK) [1,2].