While at low concentrations of IFNλs, IFNλ2 and IFNλ3 were slightly more antiviral compared to IFNλ1 against MRV (Fig 2B) and RV-UnaG infections (Fig 2C), all IFNλ subtypes conferred a dose-dependent antiviral protection against all tested viruses. Here, IFNL1 is linked to infection.