This distribution pattern is consistent with several well-characterized poxviral membrane proteins, such as VACV A33R, A36R, and B5R, which transit through host secretory and vesicular compartments and can reside on host cellular membranes at intermediate stages of infection before being incorporated into the EEV outer membrane during virion wrapping and egress [26–28]. This evidence concerns the gene CYB5R3 and infection.