CD4 and neoplasm: A recent study demonstrated increased infiltration of CD4 + and CD8 + T cells as well as CAF activation in prolactinomas among patients previously treated with CAB versus those not treated with CAB [15].These observations suggest that prolactinoma fibrosis likely reflects converging actions of tumor-intrinsic signals, stromal and immune-cell interactions, and, at least in some patients, additional DA-enhancing effects.