The association of RBM20 mutations with cardiomyopathies has directed substantial research efforts to uncover its function in the heart and to understand the impact of cardiomyopathy-associated mutations (Khan et al., 2016; Briganti et al., 2020; Schneider et al., 2020; Fenix et al., 2021). Here, RBM20 is linked to cardiomyopathy.