Current evidence demonstrates that ET-1 plays a role in thepathogenesis of endothelial dysfunction by mediating vasoconstriction, impairingvasodilation, promoting vascular remodeling, and contributing to inflammation.These properties indicate that ET-1 contributes to the pathophysiology of CVD,prompting preclinical and clinical investigations to determine whethersuppressing ET-1 activity could be clinically useful. Here, EDN1 is linked to endothelial dysfunction.