This diversity maypotentially explain the wide range of physiological and pathological effectsmediated by ET-1, including the complex role performed by ET-1 in hypertension.Receptor stimulation by ET-1 results in phospholipase C (PLC) hydrolyzingphosphatidylinositol biphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) anddiacylglycerol (DAG). Here, EDN1 is linked to hypertensive disorder.