KCNJ2 and atrial fibrillation: Similarly, research on IK1 regulation by oxidative stress has producedconflicting findings: in atrial myocytes from non-AF cardiac surgery patients,S-nitrosylation of Kir2.1 increased channel open probability, whereas in a canineatrial tachypacing model of AF, inhibition of ROS from NOX2 or mitochondria hadno effect on IK1 [124, 125].