An enrichment analysis on the top 100 ranked features (Fig. 7e) shows that while both OmNI and OmicsAnalyst’s results are strongly enriched for key cancer processes like “PI3K signaling” and “MAPK,” OmNI’s list is uniquely enriched for pathways highly specific to GBM, such as “Glioma” and “ErbB Signalling Pathway.” This superior, disease-specific enrichment visually demonstrates that OmNI’s S-score ranking provides a more comprehensive and clinically relevant biological profile. Here, EGFR is linked to central nervous system cancer.