TCF4 and cancer: In contrast, the active accessible regions displayed enrichment for motifs of many more TFs, including those associated with cMCL pathogenesis, such as TCF4 and the NF-kB-associated TF RELA [7, 26]; B-cell receptor signaling mediators such as the EGR family [27]; and KLF transcription factors with roles in the immune system and cancer [28] (Supplementary Fig. S2B and Supplementary Table S2).