Brain-derived neurotrophic factor (BDNF), matrix metallopeptidase 8(MMP8), T cell receptor alpha variable 12-2 (TRAV12-2), acidphosphatase-like 2 (ACPL2), transmembrane protein 261(TMEM261), piggyBac transposable element derived 4 pseudogene 1(PGBD4P1) and RP11-611O2.6 were identified as key hub genes inthe pathogenesis of clozapine-induced MetS in schizophrenia patients. The gene discussed is MMP8; the disease is metabolic syndrome.