Among the identified hub genes, BDNF hasbeen strongly linked to the pathogenesis of clozapine-induced MetS, with severalstudies demonstrating its role in regulating glucose metabolism, insulinresistance, and adiposity in patients treated with clozapine [26, 27].Additionally, TMEM261 appears to have partial protective roles in the context ofMetS. This evidence concerns the gene BDNF and metabolic syndrome.