EDA and ectodermal dysplasia syndrome: The disease generally has three clinical variants: hypohidrotic/anhidrotic ectodermal dysplasia also known as Christ-Siemens-Touraine syndrome, has either completely absent or drastically reduced sweat glands, it has an X-linked pattern of inheritance is caused by mutations in EDA1 gene which is located on the X chromosome [3], hidrotic or Clouston syndrome, clinically presents with hypotrichosis, palmoplantar hyperkeratosis and nail dystrophy, although has normal sweat glands.