This study aimed to evaluate the genetic diversity of the Msp1 and Msp2 genes of Plasmodium falciparum in Bamenda, North West Region of Cameroon, identify the alleles of the Msp1 and Msp2 genes that are associated with severe malaria, and determine how the alleles of the Msp1 and Msp2 genes are distributed between sexes and seasons. Here, ATAD1 is linked to malaria.