The search strategy used controlled vocabulary (MeSH and Emtree) and free-text terms related to “sodium-glucose cotransporter-2 inhibitors,” “glucagon-like peptide-1 receptor agonists,” “type 2 diabetes,” “cardiovascular outcomes,” and “randomized controlled trials.” The search was restricted to CVOTs and dedicated renal outcome trials to ensure high methodological quality and statistical power. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.