Similarly, a large cohort study in type 2 diabetic patients described that marine n-3 PUFA consumption (EPA and DHA) was linked to reduced sleep impairment progression, mechanistically connected with increased central circadian regulation through upregulation of fundamental clock genes (CLOCK, BMAL1, PER2) and RORα-mediated BMAL1 nuclear translocation, with restoration of hypothalamic clock oscillations [71]. Here, CLOCK is linked to type 2 diabetes mellitus.