These data suggest that the neuroprotective effects of PF are related to its effect against NMDA-induced calcium overload, and were supported by a previous report that reported PF can promote neuronal viability and inhibit neuronal apoptosis via down-regulation of the Ca2+/CaMKIL/CREB signaling pathway in a cerebral ischemia injury model [71]. Here, CREB1 is linked to brain ischemia.