Taking all these observations together, we concluded that PEF‐mediated suppression of gene expression of SREBP‐1c and SREBP‐2 and consequent suppression of HMGCR along with upregulation of LDLR played central roles in ameliorating HFD‐induced hyperlipidemia in Wistar rats. This evidence concerns the gene SREBF2 and hyperlipidemia.