KISS1 and neoplasm: In summary, our first pancancer analysis and experiments of KISS1, once reported as a metastasis suppressor that expressed differently in various tumors, implied a statistical correlation of KISS1 expression with clinical prognosis; immune cell infiltration, including immunosuppressive cells and lymphocytes; and tumor metastasis capacity, which adds to the understanding of the epigenetic regulatory mechanism in terms of clinical tumor samples.