Co-M: co-morbidities; T&A: adenotonsillectomy; Adx: adenoidectomy; LT: lingual tonsillectomy; T: tonsils; OSA: obstructive sleep apnea; SDB: sleep disordered breathing; DS: Down syndrome; GH: growth hormone; GDD: global developmental delay; VCP: vocal cords paralysis. This evidence concerns the gene GH1 and Global developmental delay.