cSjD = childhood Sjögren’s disease; NSAIDs = non-steroidal anti-inflammatory drugs; cDMARDs = conventional disease-modifying antirheumatic drugs; HCQ = hydroxychloroquine; MTX = methotrexate; AZA = azathioprine; MMF = mycophenolate mofetil; CYC = cyclophosphamide; RTX = rituximab; TNF = tumor necrosis factor; and IL-6 = interleukin-6; JIA = juvenile idiopathic arthritis; SLE = systemic lupus erythematosus; TIN = tubulointerstitial nephritis; NMOSD = neuromyelitis optica spectrum disorder; MALT = mucosa-associated lymphoid tissue; PH = pulmonary hypertension; - = not applicable. The gene discussed is TNF; the disease is systemic lupus erythematosus.