The primary objective of this study, therefore, was to determine the prevalence of ACA and development of meningitis among ART-naive patients with CD4 counts ≤ 200 cells/μL and ART-experienced patients with HIV viral load of ≥ 1000 copies/mL, recruited from three HIV clinics in Dar es Salaam, Tanzania. Secondarily, it aimed to determine the factors associated with the ACA and its short-term outcomes (development of meningitis, deaths, and number of hospitalizations). Predictors of CrAg positivity in the study cohort were also investigated. This evidence concerns the gene AGAP3 and meningitis.