Similarly, the preventive activities of RosA in female BALB/c mice induced asthma demonstrated that pretreatment with RosA (5–20 mg/kg) 1 h prior to the OVA challenge significantly inhibited increases in Th2 cytokines (IL‐4, IL‐5, and IL‐13) and markedly reduced IgE concentrations in the BALF (Liang et al. 2016). This evidence concerns the gene IGHE and asthma.