More fine-grained assessments of WM deterioration are critical as this deterioration is thought to occur prior to the accumulation of Aβ and possibly also AD-related tau pathology (Falangola et al., 2020; Hu et al., 2025; Wang et al., 2022) and may therefore serve as a valuable biomarker of adults at risk for later developing AD. The gene discussed is MAPT; the disease is Alzheimer disease.