Considering the three etiologies separately, no significant results were observed (trend test, PERMANOVA, AUC/BAL ACCU, correlation with CRS-R and CRS-R modified score), except for vascular patients, who showed in the precuneus a significant correlation with CRS-R and CRS-R modified; Supplementary Table 3). The gene discussed is TWIST1; the disease is congenital rubella syndrome.