Although senescent Endometrial Mesenchymal Stromal Cell (EMSC)-secreted Insulin-like Growth Factor-Binding Protein 3 (IGFBP3) (Ushakov et al., 2021) could induce senescence via telomerase inhibition, thus suppressing BC proliferation (Kwon et al., 2023), its role in PC senescence remains unclear. This evidence concerns the gene IGFBP3 and breast cancer.