APOE and Alzheimer disease: In ADGC data, after re-orienting ORs to be with reference to ε2/ε2 individuals (shown in Supplementary Table 5), a very strong increasing pattern of RRs across APOE genotypes ε2/ε3, ε3/ε3, ε2/ε4, ε3/ε4 and ε4/ε4 was observed for risk of neuropathologically confirmed AD (Table 2, Supplementary Table 4).