EWSR1 and Ewing sarcoma: This could be attributed to the higher age of patients included in later as literature shows that pediatric ES are detected earlier in comparison to adult patients.13 Although consanguinity was positive in 75% of patients in our study, there is no evidence of consanguinity as a risk factor for the occurrence of primary CNS-EES because familial cases for ES have not been reported.14 It is proposed to occur due to t (11;22)(q24;q12) translocation, which results in EWS-FLI1 fusion gene,8-10 yet the genetic testing was not performed in the majority of our patients due to resource limitations.