This is parallel to the findings of another study by Cappelli et al. who reported that normal BMI (19-24.99) is associated with good overall survival and progression free survival in glioblastoma patients.17 This might be attributed to the fact that obesity leads to insulin resistance and raised IGF-1 levels which inhibits apoptosis. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.