Although PTPN22 expression was not associated with patient prognosis in the TCGA-KIRC cohort, interestingly, in a cohort of metastatic ccRCC patients treated with ICI,27 high expression of PTPN22 was associated with improved overall survival, mirroring the response pattern observed with PD-L1 expression in ICI-treated patients (Figure S1C). Here, CD274 is linked to nonpapillary renal cell carcinoma.