In addition, analysis of total tumor-infiltrating immune cells, gated by CD45+ expression (Supplementary Fig. S19a, b), further revealed that ApoSQ-CAF CM treatment significantly decreased the population of immunosuppressive M2 TAMs and regulatory T cells (Tregs) (Fig. 6g, h), while increasing immune-stimulatory M1 TAMs and CD8+ T cells (Fig. 6i, j), compared to CAF CM. Here, CD8A is linked to neoplasm.