Immunofluorescent analysis of primary tumor tissues further revealed a dose-dependent increase in phosphorylated STAT1 within M2 TAMs (pSTAT1+/CD206+) following rWISP-1 treatment in a dose-dependent manner, whereas no significant change was observed in M1 TAMs (pSTAT1+/CD86+) (Fig. 7e-h). The gene discussed is STAT1; the disease is neoplasm.