Correlation analyses demonstrated that TAM density (CD11b+) and the proportion of M2 TAMs (CD206+/CD11b+) positively correlated with both tumor volume and the number of proliferating tumor cells (Ki67+/CD326+) 24, while showing an inverse correlation with tumor cell apoptosis (cleaved caspase-3+/CD326+) (Supplementary Fig. S18a, b). This evidence concerns the gene MRC1 and neoplasm.