Recent studies have elucidated some mechanisms underlying NPC metastasis and cisplatin chemoresistance, including USP7-mediated stabilization of KDM5B via the ZBTB16/TOP2A axis74, circIPO7-facilitated YBX1 nuclear localization75, and SOX1 drives chemoresistance in nasopharyngeal carcinoma by inducing a therapy-refractory cellular state76. The gene discussed is SOX1; the disease is nasopharyngeal carcinoma.