Importantly, validation through cross-dataset single-cell transcriptomic profiling of the NPC_GSE150430 cohort confirmed the coordinated activation of both EMT and Wnt/β-catenin signaling in MRPS7/23-overexpressing tumor cells (Fig. 3I-J), defining these mitochondrial ribosomal proteins as dual master regulators of metastatic-inductive signaling programs during nasopharyngeal carcinoma. This evidence concerns the gene MRPS7 and nasopharyngeal carcinoma.