USP10 plays an established role in promoting tumor progression in multiple malignancies, such as colorectal cancer, pancreatic ductal adenocarcinoma, osteosarcoma, esophageal squamous cell carcinoma, non-small cell lung cancer, hepatocellular carcinoma, glioblastoma, and prostate cancer39-43. The gene discussed is USP10; the disease is osteosarcoma.