Genome-wide association studies (GWAS) have revealed over 50 lung cancer susceptibility loci 4, with our previous research identifying the discoidin, CUB and LCCL domain containing 1 (DCBLD1) promoter single nucleotide polymorphism (SNP) rs17079281 C > T variant associated with reduced LUAD risk (OR = 0.86; 95% CI: 0.80-0.92). Here, DCBLD1 is linked to lung cancer.