HSPD1 and posterior cortical atrophy: In patient tissues, western blot analysis consistently demonstrated a significant upregulation of HSP60 protein in PCa tissues compared to their matched adjacent normal tissues (Fig. 1K, Fig. S1D). And HSP60 exhibited robust cytoplasmic positivity in malignant tissues (Fig. 1L-M), contrasting sharply with its minimal detection in paracancerous tissues.