HSPD1 and neoplasm: In the sh-HSPD1 knockdown model, initial tumor formation was first observed on day 15 (designated as day 0 for measurement), while tumor growth kinetics revealed robust attenuation of sh-HSPD1 tumor progression versus sh-NC controls, culminating in a 72.3% reduction in terminal tumor volume (P < 0.001) (Fig. 2O).