Likewise, the interfered STAT1 expression effectively counteracted the impact of IGF2BP2 inhibition in CAL62 cells, restoring proliferation (Fig. S4H-J) and validating that STAT1 mediates the function of IGF2BP2 in promoting thyroid cancer dedifferentiation (Fig. 8E-F) and CSCs features (Fig. 8J-L). The gene discussed is IGF2BP2; the disease is thyroid cancer.