To elucidate the mechanism by which IGF2BP2 promotes thyroid cancer dedifferentiation, we performed RNA sequencing (RNA-seq) on TPC1 cells overexpressing IGF2BP2 (TPC1-OE) and CAL62 cells with IGF2BP2 knockdown (CAL62-KD). Here, IGF2BP2 is linked to thyroid gland carcinoma.