To confirm that the inhibitory effects of AVN944 are attributable to blockade of IMPDH2 activity rather than compound-specific actions, we next tested the effects of two structurally and mechanistically distinct IMPDH2 inhibitors, MPA and SA, against Ewing's sarcoma cell lines TC71 and SK-ES-1. This evidence concerns the gene IMPDH2 and Ewing sarcoma.