In esophageal cancer (EC), METTL3 was found to first increase the m6A modification of Adenomatous polyposis coli (APC) mRNA, and then recognized by reader YTHDF2 to reduce the expression of APC and promote the expression of β-catenin and Pyruvate kinase M2 (PKM2), thereby promoting glucose uptake and lactate production51. Here, APC is linked to esophageal cancer.