METTL3 mediates mRNA shear of precursor ESRRG through m6A modification, which leads to high expression of ERRγ, and at the same time, ERRγ can bind to CPT1B promoter to activate its transcription and induce chemical resistance of tumor mediated by mitochondrial FAO process in breast and liver cancer cells229. The gene discussed is ESRRG; the disease is neoplasm.