Moreover, potentiation of the IFN-γ signaling pathway, indicated by increased IFNGR1 expression and a higher phospho-STAT1 ratio, was observed in liver lysates from both MASLD patient samples (Fig. 3S-V) and the GAN-diet-induced mouse MASLD model (Supplementary Fig. 1P-S). The gene discussed is IFNG; the disease is metabolic dysfunction-associated steatotic liver disease.