SAMHD1 and hepatocellular carcinoma: Our studies show that SAMHD1 inhibits hepatitis B virus (HBV) replication by restricting the reverse transcription of pregenomic RNA (pgRNA) into relaxed circular DNA (rcDNA) 17, and since HBV is a major HCC risk factor, we further found that nuclear SAMHD1 correlates with favorable prognosis in HCC by interacting with the cohesin complex to enhance chromatid cohesion and stall metaphase progression 18.