Given the significance of TSC2 mutations in determining the HCC subtype, we compared mutation patterns between chimpanzees and humans using two datasets (TCGA+ & ICGC) of human HCC samples bearing mutant TSC2 and one set (TCGA-) of human HCC samples without mutant TSC2 as a control group. The gene discussed is TSC2; the disease is hepatocellular carcinoma.